The work aims to simplify the box opener of drug packaging machine and improve the box opener's control accuracy, running speed and working efficiency, thus realizing the kinematic design of an electromechanical integrated box opener. The working flow of box opener was analyzed, an electromechanical integrated box opener was designed and the kinematics of each member was analyzed. The kinematic model of the box opener was established to determine the key parameters affecting the motion trajectory of the box opener. Solidworks software and Adams software were used to conduct 3D modeling and motion simulation of the box opener. The simulation results were compared with the theoretical analysis results to verify the motion rationality of the box opener. The simulation results and theoretical analysis were consistent. The motion was reasonable. The box opener could open the box according to the designed trajectory. The box opener sucks, opens and releases the box stably and reliably, the opener is simple, and the operation and maintenance are convenient. Through the control by servo motor, the control accuracy, running speed and working efficiency of box opener are effectively improved.