The work aims to study the comprehensive cost measurement of product packaging alternative in the uncertain information environment and realize the optimization of product packaging alternative. The hierarchical model of the comprehensive cost measurement index system was established, and the membership degree method was applied to standardize the initial score value of measurement index. The weight was introduced to distinguish the importance of each measurement index. The packaging alternatives were considered as the focal elements in the identification framework, and the weighted basic probability assignment value of all focal elements under each measurement index was calculated for the two-order Dempster combination. Finally, the comprehensive cost of the packaging alternatives was measured based on the confidence interval. A case study of the comprehensive cost measurement of packaging alternatives of a small electrical cabinet was carried out and the optimal packaging alternative was identified, so that the feasibility and effectiveness of the proposed method were verified. The proposed method can provide a solution to the comprehensive cost measurement of product packaging alternatives with uncertain information on the expert scores.