The work aims to study the rapid detection method of migrated mass of bisphenol S (BPS) from polyether sulfone (PES) and the migration rule of BPS. The migrated mass of BPS in simulant ethanol (volume fraction was 50%), acetic acid (mass concentration was 30 g/L) and water was rapidly detected by liquid chromatography-mass spectrometry (LC-MS). Based on that, the effect of different media, temperature, time, thickness and other factors on the migration rule of BPS was studied. The limits of detection (LOD) and quantification (LOQ) of BPS were 2.0 µg/L and 6.0 µg/L, respectively. The recoveries of the spiked standards in such simulants as water, ethanol (volume fraction was 50%) and acetic acid (mass concentration was 30 g/L) were respectively 95.2%~102%, 97.3%~102% and 96.3%~102%, with the relative standard deviation ranging from 2.6% to 4.2%, 2.6% to 4.0% and 3.3% to 4.7%. Under the same condition, the migrated mass of BPS in ethanol (volume fraction was 50%) was the highest, followed by acetic acid (30 g/L) and water. Meanwhile, the migrated mass of BPS increased as the temperature and thickness increased. BPS is detected by LC-MS. The detection method is featured by convenient operation, high flexibility, good repeatability and accurate results, etc. The property of food simulants is an important factor that affects the migration behavior of BPS; meanwhile, the temperature and thickness also affect the migration of BPS in PES.