Under the support of intelligent transportation system, large data, artificial intelligence and other technologies, the development and design of human mobility are discussed and the interactive design method of unmanned vehicle under new human mobility is studied. The methods of literature investigation, field investigation and user participation design are used to analyze the research. The expansion of human mobility for autonomous vehicles focuses on the intelligent digital information input and output processing ways, the exchange of time and space, online and offline social networks, identity information from the humans, vehicles and transportation big data, human-vehicles rapid interaction instant messages, intelligent transportation mobile network information interaction system, the knowledge graph formed by the user generated contents based on mobility, flexible information architecture based on logistic, information flow and financial flow in the cyberspace, information space and noosphere. Autonomous vehicles interaction design based on human mobility changes the concept of interaction logic, interactive function, behavior pattern, communication contents and new media. The relationships transformation of human-machine interaction model and information mapping form the new human identity. Flexible information architecture based on the mixed intelligent information in time feedforward and feedback comes from artificial intelligence dual user generated contents and human intelligence professional generated contents. The new human mobility defines the new paradigm of human machine interaction design through interaction media, interaction function and interaction contents.