The work aims to construct the Neugebauer equation correction model based on halftone solid tristimulus values according to the fact that the halftone area ink volume is different from the solid area ink volume, thus improving the calculation precision of Neugebauer equation. The standard printing documents conforming to the G7 certification were taken as the research object. Based on the fact that the halftone area ink volume was different from the solid area ink volume, a Neugebauer equation correction model based on halftone solid tristimulus values was constructed through the solution to the halftone solid tristimulus values. The color difference method was adopted to verify the accuracy of the correction model. The verification results showed that the color difference accuracy of correction model could be improved by 2.2 NBS, and the average color difference accuracy could be improved by 1.0 NBS. The Neugebauer equation correction model based on the halftone solid tristimulus values can effectively improve the equation precision. The research results are of great significance for the color separation of printing.