The work aims to propose a design scheme for the environmentally friendly, reusable, tape-free express package with respect to the issues that the express packages exit the circulation process after only used once and the tape is commonly used for sealing. Firstly, the improvable shortcomings of the existing express package were clarified via market survey. Secondly, an environmentally friendly, reusable, tape-free express package design was proposed by designing the innovative packaging structure. Furthermore, the operation process of the new design was illustrated. Finally, the package performance tests and actual transportation tests were conducted to verify the feasibility of the proposed scheme. The results of the free fall test in which the equivalent drop height was equal to 80 cm indicated that, the peak accelerations of the bottom drop of the first, second and third free fall tests were respectively 26.0g, 29.6g and 17.5g, and the peak accelerations of the second and third drops were respectively increased by 13.7% and decreased by 32.8% compared to that of the first drop. The sealing effect was still good after three repeated free fall tests. The empty container compression tests indicated that, the maximum compressive strength of the box was 2,558 N, superior to that of the regular slotted corrugated box with the same dimension. The actual transportation test showed that the proposed box could maintain its favorable performance in sealing and protection under the relatively harsh domestic transport environment. The proposed design scheme can not only achieve the function of multiple use and sealing without tape, but also provide good cushioning, sealing and environmental protection performances.