The work aims to study the factors that affect migration regulation of harmful compounds in food, so as to effectively predict the risk of pollution of packaging material on food. The effect of temperature, solubility parameter of food-simulating solvents and molecular weight of antioxidants on enthalpy change, migration partition coefficient value (Dr0) and diffusion coefficient value of BHA, BHT, 1076 and 168 from polypropylene plastics into food-simulating solvents (ethyl alcohol) was studied. The migration partition coefficient value (Dr0) was predicted with Scatchard- Hilderbrand thermodynamic theoretical model and was contrasted with experiment value (Dr). The logarithms of migration partition coefficient value (ln Dr) and migration diffusion coefficient value (ln Df) of 4 kinds of antioxidants from PP into ethyl alcohol absolute exhibited a linear relationship with eciprocal of temperature (1/T) and followed Gibbs-helmholtz equation and Arrhenius equation, respectively. Migration was an endothermic reaction. The enthalpy change decreased with the increase of molecular weight of antioxidants, and migration diffusion coefficient value in-creased as molecular weight of antioxidants and solubility parameter of food-simulating solvents decreased; meanwhile, migration partition coefficient (food-simulating solvents mass concentration/plastics mass concentration) experiment value of the antioxidant from polypropylene into the food-simulating solvents with various solubility parameters was basically consistent with Scatchard-Hilderbrand thermodynamic calculating value in variation trend of solubility parameter of food-simulating solvents. The less the solubility parameter difference value between stimulants and PP is, the larger diffusion coefficient value is, and the smaller influence of molecular weight of antioxidants on diffusion coefficient value is. The variation on migration partition coefficient of 4 kinds of antioxidants from PP into various food-simulating solvents accords with Scatchard-Hilderbrand thermodynamic theoretical model.