The work aims to conduct experimental investigation and finite element analysis on the static compression process of the vertical corrugated composite paperboard, and study the mechanical properties of different flute vertical corrugated composite paperboards. Three different vertical corrugated composite paperboards of A flute, AB flute and B flute were fabricated, and the compressive stress-strain curves were obtained after the static compression test. The finite element models of three vertical corrugated composite paperboards were established and the compressive stress- strain curves were obtained after statics analysis. The two kinds of curves were compared with the experimental results and analyzed. Both experiment and finite element analysis showed that the static compression process of vertical corrugated composite paperboard was similar to that of the honeycomb paperboard, including elastic stage, yield stage, platform stage and densification stage. The compressive stress-strain curves obtained from the experiment and finite element analysis fit well. The peak stress and the platform stress of the paperboard were related to flutes and decreased with the increase of the flute height. Static compression properties of different flute vertical corrugated composite paperboards are obtained in the methods of experimental investigation and finite element analysis. They have important reference value for the application of this new material.