The work aims to improve the production efficiency of beer filling production line, elevate the automation degree of liquor making enterprises and reduce the labor intensity of workers. According to the beer filling process and the structure of automatic filling production line, a control system of automatic beer filling production line based on PLC and touch screen was proposed. The control system took the Panasonic FP-XHC60R PLC as the controller core and the MT6070I touch screen as the human machine operation interface to realize the automatic control and the feedback control of the actuator through the PLC. The production line operation parameters were set up and the production line operation condition was monitored by the HMI human machine touch screen. Based on this hardware structure, the software design of the control system was completed; and according to the single neuron control theory, a kind of beer filling level adaptive control algorithm was proposed to improve the control precision of the filling level. The control system has a simple structure convenient for operators to carry out humanized management of the equipment. The control system of beer filling production line designed has the advantages of high production efficiency, high automation and stable operation.