The work aims to reduce the possibility of damage or failure for the internal components in the microwave oven during transportation due to vibration. The structural characteristics of microwave oven products were analyzed. The vibration isolation-buffer performance of microwave oven product’s packaging system was studied. The mechanical model for the vibration isolation-buffer performance of packaging system with six degrees of freedom (including the horizontal motion along x, y and z and the rotation around x, y and z) and the dynamic equation were established. The vibration response of the vibration isolation-buffer system was simulated by computer numerical simulation, and the acceleration peak value obtained was 1.1131 m/s2. Based on the theoretical modeling, the experimental device of the microwave oven product’s packaging system was made. The actual acceleration peak value obtained from the vibration experiment was 1.2901 m/s2. The error was 11.08% compared with the result of computer simulation, which was within the allowable error range of the project. The proposed vibration isolation-buffer design and evaluation method for packaging system is theoretically reliable, which can provide theoretical basis and effective reference for the design of vibration isolation-buffer design of microwave oven products.