The work aims to design a kind of spliced plastic corrugated turnover box which can replace plastic turnover box and corrugated box, and search the fragile parts of the designed plastic corrugated turnover box during drop through simulation, so as to make a more reasonable design and optimization of the designed structure. The model simulation on the drop during the daily transportation was carried out based on HyperMesh LS-DYNA and LS-Pre Post. When the total weight of the box was 60 kg and the height was 1 m, the drop simulation was conducted respectively under the conditions of 15° inclined angle and the horizontal level (angle between the box bottom and the drop ground). When the bound frames at the bottom of the designed turnover box collided under these two conditions, the von mises stress of partial frame was more than 200 MPa which exceeded the yield strength of aluminum alloy and caused plastic deformation, but the effective plastic strain of the frame did not reach the aluminum alloy's section elongation (16%), thus resulting in no fracture failure. The designed turnover box has outstanding anti-dropping capability, and the strengthened protection design of the four base angles should be emphasized during the improvement.