The work aims to design a foldable cold chain transport insulation container in order to reduce the space for empty container transport and storage of the insulation container. The effect of different path lengths at thermal bridge joint on the thermal insulation performance of the insulation container was researched. The structure with the path length at the part subject to the minimum thermal bridge effect was selected as the structure at the joint of foldable insulation container to make the foldable insulation container. The difference of thermal insulation performance between the foldable insulation container and the whole one could be explored. The features of foldable insulation container in both transport distribution and warehouse management were demonstrated. The longer the thermal bridge path at the joint, the weaker the thermal bridge effect, thus the better the thermal insulation. The shortest temperature holding time appeared on the upper corner of the foldable and the whole insulation containers, and the temperature holding time difference between the two types of containers was 30 min, only 3.8% of the total duration. The thermal insulation performance of the foldable insulation container is close to that of the whole one, which can meet the thermal insulation requirements.