The work aims to design a kind of intelligent logistics packaging system for vaccine based on the characteristics of the vaccine and the deficiency of China's vaccine logistics packaging supervision system. The internet of things, wireless communication, sensor and other technologies were integrated into the traditional vaccine logistics packaging to solve the problems in traditional vaccine logistics packaging and achieve the vaccine intelligent logistics packaging based on the analysis of the current situation of vaccine logistics packaging. The system mainly consisted of the logistics packaging module and intelligent material union module. The logistics packaging module ensured the safety of packaging dynamics and physical and chemical properties of vaccine through the packaging structure design. The intelligent material union module could monitor the main parameters of vaccine information (such as temperature, geographical distribution) in real time to achieve comprehensive traceability of vaccine quality information and establish the early warning mechanism of temperature information security by means of technical integration. The system can provide a safer and more reliable logistics package for the vaccine supply and facilitate the relevant departments to grasp the real-time and effective information on the vaccine.