The work aims to develop a new type of digitized packaging box with functions of tampering- evidence, compression resistance and reusability. With the corrugated paperboard as the box material, the design scheme for the structure of digitized packaging box with functions of tampering-evidence, compression resistance and reusability was obtained by printing QR code, AR identification area, bar code and security code on the box. The tampering-evidence, reusability, digitization and other functions of the packaging box were tested, and its compression properties were analyzed. Compared with the ordinary packaging box, the special design of the proposed packaging box was made in terms of the safety, compression strength and reusability. Moreover, the addition of the digitized element design could improve the consumer experience to some extent and enable the commodities to achieve so many functions, such as tampering-evidence, traceability, anti-channel conflict and micro-marketing. In addition, the digitized packaging box could promote the electronic express waybills, and enhance the confidentiality and security of personal information. The proposed packaging box can solve the problems of reusability failure, lower security and compression properties and shortage of digital applications in the ordinary packaging box based on the existing technology through the special structure design.