The work aims to predict the optimal installation and usage requirements of gravure scraper. Liquid-solid coupling analysis was carried out by respectively establishing ink fluid model and scraper solid model with the analysis software. Under the influence of ink impact, with the increase of installation angle, the displacement change rate of the blade was obviously decreased, and the blade displacement gradually decreased with the increase of the scraper thickness. It was verified that, in the printing process of the flexible package, the optimal installation angle of the scraper was 55°~65°, and the 0.15 mm thick scraper was easily selected. When the elongation was 5~6 mm, the scraper could be in the best scraping state. The proposed study provides a reference for the rational selection and design of the scraper; at the same time, the method of liquid-solid coupling analysis of the gravure printing process has some practical and theoretical significance for the quantitative analysis of printing process.