The work aims to develop a dedicated cam profile CAD system for a common type of cam linkage system in packaging machinery based on the secondary development of ADAMS. ADAMS was used to provide an intuitive assessment method for the influence of cam profile on the dynamic stability of the system. According to the structural characteristics of the cam linkage system, the ADAMS command language was used to complete the development of CAD system. With the long swing arm of cam linkage system as the research object, through the ADAMS rigid-flexible coupling simulation analysis, the related indicators of dynamic stability of the actuating members were compared when the cam designed based on different acceleration motion laws of the sine and the modified sine was running at high speeds, thus verifying the correctness of rigid-flexible coupling simulation analysis applied to the cam linkage system. The actual maximum speed, the maximum acceleration, the maximum fluctuation of the actual displacement curve and other evaluation indicators of dynamic stability were better when the cam designed based on the modified sine acceleration motion law was applied, which was in line with the theoretical analysis. ADAMS rigid-flexible coupling simulation results can correctly reflect the influence of cam profile on the dynamic stability of the system. This analysis method helps to design a more rational cam profile.