The work aims to collect the uneven spectrum of the road surface by the sensor in collaboration with the data acquisition card, and match the road surface information with the standard road level and the vehicle running speed. The standard PSD and random excitation were used to match the road level through Matlab. The dynamic model of 1/2 four axle heavy truck was established, and the kinetic equation was established by energy method. The dynamic load displacement spectrum of the excited tire was finally obtained by matching the collected uneven spectrum of road surface with the corresponding road level and then combined with the vehicle speed setting, and then the dynamic load displacement of the semi-trailer plate of the transported packaged articles was obtained through analysis. For the front transportation axle tire of the heavy truck running on the class A pavement at a speed of 60 km/h and passing by such uneven spectrum of road surface, the dynamic load displacement reached its peak respectively at 0.8 and 9.8 s, and the pavement response displacement should not exceed 6 cm. The excited spectrum of the transported packaged articles is obtained, which can provide support for the safety research of the transportation vibration of the packaged articles. Combined with the fragility theory of a specific transported packaged article, the numerical simulation of the transported articles subject to damage in transit is provided.