The work aims to study the cushioning structure of egg products packaged with EPE material during the E-commerce logistics. The EPE material was used to design three kinds of egg holder cushioning structures of the round, square and quincuncial shape. The outer package was the corrugated box. The drop test of the packages was simulated with the drop tester. Through the drop test of three kinds of packages, the maximum response accelerations were respectively 31.26g, 43.76g and 46.25g, all of which were smaller than the egg fragility (50g). The maximum response acceleration of the round egg holder during the drop was the least, due to which the eggs could be protected in the best manner. As long as the cushioning structure is reasonably designed, EPE can fully meet the requirements of the egg packaging for E-commerce logistics.