The work aims to establish the quality prediction model of cold-fresh chicken (CFC) supply chain. The links, such as CFC production, loading, unloading, handling, transportation and sale in the CFC supply chain were analyzed and studied by applying the safety reliability. From the view of cost and safety, the dynamic optimization of each link of CFC supply chain in different circumstances was carried out through variable weight vector to achieve the double balance of cost control and quality assurance. Moreover, the specific optimization process was illustrated by examples. The prediction model of CFC supply chain established was valid. The safety reliability of CFC supply chain could be effectively distributed by adjusting some weight parameter. The promotion and application of CFC policy and the guarantee of food safety have certain practical reference value.