The work aims to study the correlativity between the structural parameters and compressive strength of the tube-shaped folder boxes, so as to provide the basis for the design optimization of box structure and its compressive strength. Firstly, three typical tube-shaped folder boxes, including the common, the quadrangular frustum pyramid and the flower-lock-tuck ones, were designed to further determine the key structural parameters of the three kinds of boxes that affected the compressive strength. Secondly, with each structural parameter as the independent variable in order, and the remaining structural parameters as the constants, the box compression tester was used to carry out the empty container compression test and record their respective maximum crush force. Finally, the experimental data were analyzed to clarify the correlativity between the compressive strength and the structural parameters. The compressive strengths of the three kinds of boxes increased with the increase of the circumference. However, not all the compressive strengths were reduced with the increase of the height. In considering the circumference, the compressive strength of the common box was the best. Whereas, the compressive strength of the flower-lock-tuck box was the best in considering the height. Given the box types, the compressive strength was the optimal under the conditions that the length to width ratio of the common boxes approached 1.0, the bottom to top ratio of the quadrangular frustum pyramid box was within the range of 1.2~1.4, and the angle between the line of coincident point-circle center and the horizontal line approached 30° of the flower-lock-tuck box. The compressive strength of the tube-shaped folder boxes was overall superior than that of the regular slotted boxes due to the effects of the structural parameters. The key structural parameters of the tube-shaped folder boxes significantly affect the compressive strength. Therefore, more attention should be paid to the design of the tube-shaped folder boxes.