The work aims to study the stress and deformation of the red wine package in the process of dropping and optimize the design of buffering cushion. Ansys Workbench was used to build the physical model of the red wine package. Moreover, the stress and deformation of the package were analyzed according to the results of drop simulation. A multi-objective optimization design of the red wine package was carried out, with the thickness of cushion base and the cushion wall height as the design variables, and the overall deformation and cushion mass as the optimization objectives. The maximum deformation of the package was 137.01 mm, the thickness of the optimized cushion base was 23.06 mm, and the cushion wall height was 183.1 mm. The best scheme was found under the premise that the cushion mass remains basically unchanged. The scheme further improves the protection capability of the red wine and reduces the breakage rate of the red wine when it falls.