The work aims to propose a full-paper packaging design scheme with respect to the problems existing in the packages for small/medium-sized potted plants of traditional E-commerce. Firstly, the characteristics of small/medium- sized potted plants were analyzed. Furthermore, the packaging structure consisting of the integrally nested interior and exterior boxes was proposed. Secondly, the free drop tests were performed to verify the protection of the design scheme. Improvement measures were further put forward for the deficiencies during the tests. Finally, the drop, vibration and compression tests were respectively performed for the improved design, to comprehensively verify the feasibility of the scheme. Moreover, the cost accounting of the design scheme was conducted to clarify the economy. The results of the free drop tests at the height of 60 cm showed that, the angle-drop impact was the most rigorous, and the peak acceleration approached 25g, which was far smaller than the fragility range (90g~120g) of the potted plants. The 60 min random vibration test was conducted to simulate a road transportation environment. The test results showed that the package had good vibration absorption performance. The empty container compression test indicated that, the maximum average crash force of the package was 727 N, which could meet the stacking requirements of E-commerce logistical environment; while the maximum average crash force of the full package from the compression test reached 2117 N, which approximately was 3 times the size of the empty container. The cost accounting indicated that the cost of a single set of design scheme was not higher than 5% of the total product value. The proposed packaging scheme meets the concept of green packaging, has good cushioning, vibration isolation and stacking performances, and is cost-effective.