目的 检测药品包装材料使用的粘合剂中甲苯二异氰酸酯（2, 4-TDI）单体的残留量。方法 用乙腈提取样品后，与衍生剂1, 2-吡啶哌嗪溶液进行衍生化反应，然后采用反相高效液相色谱法测定衍生物，从而计算2, 4-TDI单体残留量，并进行方法学考察。结果 衍生物的线性范围为0～1.2 μg/mL（线性相关系数R=0.9998, 线性拟合点数n=7）；精密度的相对标准偏差为1.52%；24 h内稳定性的相对标准偏差为2.51%；回收率平均值为102.63%，回收率的相对标准偏差为1.79%。结论 建立的方法可靠、结果准确、稳定性好、专属性强，能够快速测定衍生物的含量，从而计算2, 4-TDI单体的残留量，为药品包装材料所使用的粘合剂中2, 4-TDI单体残留量的检测提供有力支持。

The work aims to test the 2, 4-TDI monomer residue of the adhesive used in the drug packaging materials. The sample was extracted with acetonitrile and derivatived with 1, 2-pyridyl piperazine. Then, the derived product was tested with RP-HPLC, thus calculating the 2, 4-TDI monomer residue and investigating the methodology. The linear range of derivative was 0~1.2 μg/mL (linearly dependent coefficient R=0.9998, and number of linear fitting points n=7). The relative standard deviation (RSD) of precision was 1.52%. RSD of stability in 24 h was 2.51%. The mean recovery was 102.63% and the RSD of recovery was 1.79%. The method established is reliable, accurate, stable and specific, and can be used to test the content of derived product rapidly, thus calculating 2, 4-TDI monomer residue, and providing powerful support for the test of 2, 4-TDI monomer residue in the adhesive used by the drug packaging materials.