目的 基于耐溶剂性原则选择硝酸异丙酯的密封材料。方法 通过溶解度参数的计算验证丁腈橡胶（NBR）与IPN会产生溶胀效应。根据聚合物的耐溶剂性原则，选择三元乙丙橡胶（EPDM）和聚四氟乙烯（PTFE）代替丁腈橡胶，而后比较各材料与IPN的溶解度参数差值。结果 IPN在NBR的可溶球体范围内，两者的三维溶解度参数十分接近；IPN，EPDM与PTFE的一维溶解度参数分别为8.6，7.7，5.14，EPDM与IPN的溶解度参数较为接近；PTFE与IPN的溶解度参数相差较大。结论 EPDM与PTFE均比NBR更适合密封IPN，其中EPDM最适合密封IPN。

The work aims to select the sealing material of isopropyl nitrate (IPN) based on the solvent resistance principle. The fact that nitrile rubber (NBR) and IPN would result in swelling effect was verified by calculating the solubility parameters. According to the principle of solvent resistance, EPDM rubber and polytetrafluoroethylene (PTFE) were selected instead of NBR. Then, the difference between the solubility parameters of each material and IPN was compared. IPN was within the range of NBR soluble sphere and the three-dimensional solubility parameters of both were very close. The one-dimensional solubility parameters of IPN, EPDM and PTFE were 8.6, 7.7 and 5.14, respectively. The solubility parameters of EPDM and IPN were close to each other; the solubility parameters of PTFE and IPN were quite different. EPDM and PTFE are more suitable for sealing IPN than NBR, and EPDM is the most suitable for sealing IPN.