目的 提出样条插值亚像素边缘检测方法，以提高药品容器密封性检测的准确率。方法 采用一种改进的亚像素边缘检测方法，首先将抖动的模糊图像进行复原，复原后的图像经过预处理后，再采用改进的形态学梯度的样条插值亚像素边缘检测方法，以提高容器密封性检测的效率和准确率，并在此基础上进行模拟实验。结果 该方法的检测准确率均在95%以上，传统方法很难达到这样的效果。结论 该方法能够很好地解决传统检测方法效率低的问题，可以满足实际的检测需求。

The work aims to propose a method for sample pixel edge detection of spline interpolation, so as to improve the accuracy of detecting the tightness of drug container. An improved sub-pixel edge detection method was adopted. Firstly, the shaking blurred image was recovered. After the preprocessing of the recovered image, the spline interpolation sub-pixel edge detection method of the improved morphological gradient was used to improve the efficiency and accuracy to detect the container tightness. Based on that, the simulation experiment was conducted. The detection accuracy of such method was above 95%. It was very hard for the traditional method to achieve such effect. The method can solve the problem of low efficiency of traditional detection methods properly, and it can meet the actual detection needs.