The work aims to research the R&D progress of environmental printing ink-cleaner, in order to explore the research strategy for the technology upgrading of such cleaner. Regarding semi-aqueous ink cleaner and aqueous ink-cleaner as the research objects, the effect of decontamination, security, environmental friendliness and antiseptic properties of different types of environmental ink cleaners were elaborated and the future development trend of environmental ink cleaners was forecasted. According to the analysis on the advantages and disadvantages of different ink cleaners, it concludes that plant oil-based ink cleaner and aqueous ink-cleaner will have broad application and development prospects in the future.