目的 建立气相色谱/质谱法测定食品模拟物中2,2,4,4-四甲基-1,3-环丁二醇（TMCD）迁移量的方法。方法 食品模拟物经甲醇提取后，采用DB-5ms色谱柱程序升温分离，以72作为目标离子，用外标法进行定量。结果 水基模拟物中的TMCD在0.25～25.0 mg/L范围内线性良好，定量限为0.25 mg/L;脂类食品模拟物（橄榄油）中的TMCD在1.25～25.0 mg/L范围内线性良好，定量限为1.25 mg/L;相关系数均不小于0.995，回收率为82.2%～106.9%，相对标准偏差（n=6）为0.3%～8.1%。结论 该方法快速、准确、灵敏，适用于食品模拟物中2,2,4,4-四甲基-1,3-环丁二醇(TMCD)迁移量的测定。

This paper aims to study the determination of 1,3-Cyclobutanediol,2,2,4,4-tetramethyl in food simulants by HS-GC-MS method. After extracted by methanol aqueous simulation, the target compound was separated on the DB-5ms. The external standard method was used with 72 as target ions. In the water-based analog of TMCD by this method, the linear plots were obtained between 0.25 and 25.0 mg/L, the limits of quantification (LOQs) was 0.25 mg/L. In the olive oil analog of TMCD by this method, the linear plots were obtained between 1.25 mg/L and 25.0 mg/L, the limits of quantification (LOQs) was 1.25 mg/L. With the correlation coefficients no less than 0.995; the spiked recoveries of real cosmetics were in the range of 82.2%～106.9%, RSD (n=6) value at 0.3%~8.1%. In conclusion, this method has been proved to be simple, rapid and widely applicable, and is applicable to determining TMCD in water-based analog.