目的 研究羧甲基壳聚糖溶液浓度和静电纺丝工艺参数对纳米纤维直径的影响。 方法 按照静电纺丝的原理，选取溶液浓度、电压、流量和喷头直径等 4 个影响因素，使用响应面法中的Box-Behnken 设计对羧甲基壳聚糖静电纺丝纤维直径进行预测，得到二次多元回归模型。 结果 羧甲基壳聚糖溶液浓度、流量、浓度的二次项和喷头直径的二次项对纤维直径影响显著，该模型实验值与预测值高度拟合。 结论 通过响应面得到的模型能预测羧甲基壳聚糖纤维的直径，同时明确了羧甲基壳聚糖纤维的最佳电纺参数。

The aim of this work was to study the influences of the concentration of carboxymethyl chitosan solution and the process parameters of electrospinning on the diameter of the nanofibers. According to the principle of electrostatic spinning, this paper chose 4 influencing factors, including solution concentration, voltage, flow rate and nozzle diameter, and adopted the Box-Behnken design in response surface methodology (RSM) to predict the diameter of carboxymethyl chitosan nanofibers prepared by electrospinning, obtaining a quadratic regression model. The results showed that the concentration, flow rate, quadratic of concentration and quadratic of nozzle diameter had significant influences on the diameter of the nanofibers. There was high consistency between the experimental values and the prediction values. The model obtained through response surface method could not only predict the diameter of carboxymethyl chitosan fibers, but also determined the optimal electrospinning parameters of carboxymethyl chitosan fibers.