目的 研究纳米材料在SPR生物传感器中的应用进展。方法 介绍表面等离子共振（SPR）原理和近几年来纳米材料在SPR生物传感器中的应用研究现状， 并重点综述常见的几种纳米材料 （包括金纳米粒子、 金纳米棒、 银纳米粒子、 磁纳米粒子、 石墨烯和量子点）在 SPR 生物传感器中的应用新进展。结果 SPR 生物传感器是对表面折射率变化敏感的一项分析技术， 然而， 传统的 SPR传感器无法检测极小的折射率变化， 这就阻碍了其在超灵敏检测中的应用。结论 采用纳米材料提高SPR检测灵敏度和特异性是SPR技术发展的必然趋势。

To study the research progress in application of nanomaterials in the surface plasmon resonance (SPR) biosensor. The principle of SPR and the application of nanomaterials in SPR biosensors in recent years were reviewed in this paper. The research and application of several nanomaterials (gold nanoparticles, gold nanorods, silver nanoparticles, magnetic nanoparticles, graphene and quantum dots) were emphatically summarized. SPR is a surface-sensitive analytical technique based on the detection of changes in the refractive index. However, conventional SPR is unable to measure extremely small changes in the refractive index, which hinders its application in ultrasensitive detection. Using nanomaterials to improve the detection sensitivity and specificity is a developmental direction for SPR biosensor in the future.