The geometric model of isothermal blow molding process was established. Based on the material of shear-rate dependence of viscosity model, the task was established by the simulation software Polyflow. The computer simulation was implemented with the reset grid technology. The thickness change of parison, contacting time of parison and mold in the blow, and the effect of blowing pressure on inflation time and wall thickness were obtained. The purpose was to provide reference for wall thickness control of blow molding process.