During in printing quality inspection, the inspection of hue error is an important content. Geometrical lookup table with interpolation was applied to process the color space transformation (RGB to Lab) based on the registration of standard printed mater and printing mater. Firstly, source color space was divided unevenly and the relevant lookup table was established. The divided grids were transformed to target color space with tetrahedron geometrical interpolation algorithm. The color difference of corresponding points was calculated and the distribution of color difference was analyzed. The results were used to evaluate the color deflection of presswork. It was proved that this method has good effect.