GC-MS法同时测定食品接触材料及制品中3种甲酚异构体迁移量

曾铭; 阿文伟; 区宇程; 吴泽春; 梁约; 梁炜锋; 范颖莹; 陈湘颖; 李天广; 李丹

doi:10.19554/j.cnki.1001-3563.2025.23.011

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包装工程（技术栏目） ›› 2025, Vol. 46 ›› Issue (23) : 106-112. DOI: 10.19554/j.cnki.1001-3563.2025.23.011

健康营养食品包装开放式创新与产业化

GC-MS法同时测定食品接触材料及制品中3种甲酚异构体迁移量

曾铭¹, 阿文伟¹, 区宇程¹, 吴泽春¹, 梁约¹, 梁炜锋¹, 范颖莹¹, 陈湘颖¹, 李天广², 李丹^1,*

作者信息 +

Simultaneous Determination of Migration Levels of Three Cresol isomers in Food Contact Materials and Articles by Gas Chromatography-mass Spectrometry

ZENG Ming¹, A Wenwei¹, OU Yucheng¹, WU Zechun¹, LIANG Yue¹, LIANG Weifeng¹, FAN Yingying¹, CHEN Xiangying¹, LI Tianguang², LI Dan^1,*

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摘要

目的为评估邻甲酚、间甲酚和对甲酚的迁移风险,建立GC-MS法测定食品接触材料及制品中3种甲酚异构体迁移量的分析方法。方法对于水基、酸性和含乙醇食品模拟物,用二氯甲烷进行萃取;对于橄榄油模拟物,用乙腈进行萃取;对于化学替代溶剂（95%乙醇和异辛烷）,则采用直接液体进样方式,通过气相色谱-质谱法测定、外标法定量。结果 3种甲酚异构体在0.30~3.0 mg/kg范围内有着良好的线性关系,相关系数大于0.997,方法的检出限均为0.1 mg/kg,定量限均为0.30 mg/kg,加标回收率在85.5%~110%之间,相对标准偏差（n=6）为1.9%~9.4%,通过对实际样品进行测试和评估,表明此方法具备较高的准确度和可靠性。结论该方法适用于食品接触材料及制品中甲酚迁移量的测定。

Abstract

The work aims to evaluate the migration risk of o-cresol, m-cresol, and p-cresol by establishing a GC-MS method to determine the migration levels of these three cresol isomers in food contact materials and articles. For aqueous, acidic, and ethanol-containing food simulants, dichloromethane was used for extraction. For olive oil simulants, acetonitrile was employed. For chemical alternative solvents (95% ethanol and isooctane), direct liquid injection was adopted. The analysis was performed by gas chromatography-mass spectrometry (GC-MS) with external standard quantification. The three cresol isomers demonstrated good linearity within the concentration range of 0.30 to 3.0 mg/kg, with correlation coefficients exceeding 0.997. The method exhibited a limit of detection (LOD) of 0.1 mg/kg and a limit of quantification (LOQ) of 0.30 mg/kg for all analytes. Spiked recovery rates ranged from 85.5% to 110%, with relative standard deviations (RSD, n=6) between 1.9% and 9.4%. Testing and evaluation of actual samples demonstrated that this method exhibits high accuracy and reliability. This method is suitable for determining the migration levels of cresols in food contact materials and articles.

导出引用

曾铭, 阿文伟, 区宇程, 吴泽春, 梁约, 梁炜锋, 范颖莹, 陈湘颖, 李天广, 李丹. GC-MS法同时测定食品接触材料及制品中3种甲酚异构体迁移量[J]. 包装工程. 2025, 46(23): 106-112 https://doi.org/10.19554/j.cnki.1001-3563.2025.23.011

ZENG Ming, A Wenwei, OU Yucheng, WU Zechun, LIANG Yue, LIANG Weifeng, FAN Yingying, CHEN Xiangying, LI Tianguang, LI Dan. Simultaneous Determination of Migration Levels of Three Cresol isomers in Food Contact Materials and Articles by Gas Chromatography-mass Spectrometry[J]. Packaging Engineering. 2025, 46(23): 106-112 https://doi.org/10.19554/j.cnki.1001-3563.2025.23.011

中图分类号： TB484

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