目的 探究化妆品与丁腈橡胶胶帽的相容性，为后续丁腈橡胶在化妆品滴管瓶中的应用提供理论支撑。方法 使用傅里叶变换红外光谱(FTIR)、核磁共振(NMR)、气相色谱-质谱联用(GC-MS)、X射线荧光光谱法(XRF)、质谱(MS)、电感耦合等离子体(ICP)等分析技术，分析各条件下相容性测试溶液及包装材料本身的化学组成。结果 以丁腈橡胶为胶帽材质的滴管玻璃瓶，胶帽成型所用的增塑剂会在高温时从化妆品溶液中析出或与醇类反应，胶帽中硫化剂在高温下也会迁移使溶液变黄。结论 丁腈橡胶中的塑化剂成分与内容物中醇类物质(丁二醇、丙二醇、戊二醇)存在不兼容现象。

The work aims to study the compatibility of commonly used preservative system components in cosmetic contents with nitrile rubber caps to provide theoretical support for the subsequent application of nitrile rubber in cosmetic dropper bottles. Experiments were conducted to analyze the chemical composition of the compatibility reaction solution using FTIR, NMR, GC-MS, XRF, MS, ICP and other instruments. The results indicated that, for glass dropper bottles of nitrile rubber caps, the plasticizer used for cap molding would precipitate from the cosmetic solution or react with alcohol at high temperature, and the vulcanizing agent in the cap would also migrate at high temperature, making the solution yellow. In conclusion, the plasticizer components in nitrile rubber are incompatible with the alcohols (such as butylene glycol, propylene glycol, pentylene glycol) in cosmetics.