目的 在温和实验条件下制备卤胺季铵盐双活性抗菌剂，考察其抗菌活性并研究其在纤维基包装材料中的应用。方法 利用紫外-可见分光光度计标定标准曲线，考察双活性抗菌剂及负载该抗菌剂的纤维基包装材料的抗菌活性和再生复用性能。结果 双活性抗菌剂在质量浓度为0.25 g/mL时，15 min内对大肠杆菌和金黄色葡萄球菌的杀菌效果均达到100%;负载双活性抗菌剂的纤维基包装材料在15 min内对大肠杆菌和金黄色葡萄球菌的杀菌效果均达到100%;经3次抗菌性能再生后，双活性抗菌剂和纤维基抗菌包装材料的一次杀菌效果仍可达到100%。结论 双活性抗菌剂对革兰氏阴性菌(大肠杆菌)与革兰氏阳性菌(金黄色葡萄球菌)均有良好的灭菌作用，负载双活性抗菌剂的纤维基材料的灭菌效果良好，且抗菌性能可多次再生。

The work aims to prepare dual-active antibacterial agent (DAA) with halogenated amine and quaternary ammonium in mild experiment conditions to investigate its antibacterial activities and its application in fiber-based packaging materials. The standard curve was calibrated with an UV-visible spectrophotometer to investigate the antibacterial activities as well as regeneration and reuse performance of DAA and FAPM carrying the DAA. The results indicated that the sterilization rates of DAA (0.25 g/mL aqueous solution) and FAPM to Escherichia coli and Staphylococcus aureus were all 100% within 15 minutes. After regeneration for 3 times, the sterilization of DAA and FAPM could still reach 100%. In conclusion, DAA has good sterilization effect on Gram-negative bacteria (Escherichia coli) and Galanz-positive bacteria (Staphylococcus aureus). The fiber-based materials carrying DAA have good sterilization effect, and their antibacterial properties can be regenerated many times.