目的对制备的水降解材料聚乙烯醇包装薄膜进行溶解度测试，并用薄膜降解溶液对小鼠进行急性毒性实验以评价其生物安全性。方法将水降解材料聚乙烯醇包装薄膜和水按照一定比例进行分装，通过范围分析和定量分析确定薄膜在水中的溶解度。根据溶解度对ICR小鼠设置9，3，1 g/kg的浓度梯度实验组，对C57小鼠设置薄膜可溶解浓度最大的9 g/kg灌胃实验组，随后根据GB 15193.3—2014进行小鼠急性毒性研究。结果水降解材料聚乙烯醇包装薄膜与水的溶解比例约为1 g︰110 g，溶解度约为9 g/kg。在14 d的急性毒性实验观察期内，小鼠均未出现急性毒性反应及死亡现象，且小鼠的体质量无明显变化。结论该水降解材料聚乙烯醇包装薄膜具有良好的生物安全性。

The work aims to test the solubility of polyvinyl alcohol packaging film of water-degradable material, and to evaluate its biological safety by acute toxicity test in mice with film-degrading solution. Polyvinyl alcohol packaging film and water were separated according to a certain proportion. The solubility of the film in water was determined by rough measurement and fine measurement. The ICR mice were divided into 9, 3, 1 g/kg concentration gradient groups according to solubility, and the C57 mice were set as the gavage group with the maximum soluble concentration of film of 9 g/kg. Then, the acute toxicity was studied according to GB15193.3—2014 standard. The solubility ratio of water-degradable polyvinyl alcohol packaging film to water was about 1 g :110 g and the solubility was about 9 g/kg. During the 14-day observation period of acute toxicity test, no acute toxicity reaction and death occurred in the experimental mice, and there was no significant change in body weight. The polyvinyl alcohol packaging film of water-degradable material has good biological safety.